CBFA2T3

CBFA2T3

Core-binding factor, runt domain, alpha subunit 2; translocated to, 3
PDB rendering based on 2h7b.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; ETO2; MTG16; MTGR2; ZMYND4
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
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Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene.[1][2]

Function

The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.[2]

Interactions

CBFA2T3 has been shown to interact with:

References

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Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.