Integrin, alpha X (complement component 3 receptor 4 subunit)
PDB rendering based on 1n3y.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CD11C; SLEB6
External IDs ChEMBL: GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .[1] [2] CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[1]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.


  • See also 1
  • References 2
  • Further reading 3
  • External links 4

See also


  1. ^ a b "Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)". 
  2. ^ "Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry". 

Further reading

  • Stewart M, Thiel M, Hogg N (1996). "Leukocyte integrins.". Curr. Opin. Cell Biol. 7 (5): 690–6.  
  • Steinman RM, Pack M, Inaba K (1997). "Dendritic cells in the T-cell areas of lymphoid organs.". Immunol. Rev. 156 (1): 25–37.  
  • Córbi AL, Lopéz-Rodríguez C (1997). "CD11c integrin gene promoter activity during myeloid differentiation.". Leuk. Lymphoma 25 (5-6): 415–25.  
  • Ugarova TP, Yakubenko VP (2001). "Recognition of fibrinogen by leukocyte integrins.". Ann. N. Y. Acad. Sci. 936 (1): 368–85.  
  • Valentin A, Lundin K, Patarroyo M, Asjö B (1990). "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells.". J. Immunol. 144 (3): 934–7.  
  • Gaidano G, Bergui L, Schena M; et al. (1990). "Integrin distribution and cytoskeleton organization in normal and malignant monocytes.". Leukemia 4 (10): 682–7.  
  • Corbi AL, Garcia-Aguilar J, Springer TA (1990). "Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.". J. Biol. Chem. 265 (5): 2782–8.  
  • Corbi AL, Larson RS, Kishimoto TK; et al. (1988). "Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.". J. Exp. Med. 167 (5): 1597–607.  
  • Corbi AL, Miller LJ, O'Connor K; et al. (1988). "cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.". EMBO J. 6 (13): 4023–8.  
  • Miller LJ, Wiebe M, Springer TA (1987). "Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins.". J. Immunol. 138 (8): 2381–3.  
  • Bilsland CA, Diamond MS, Springer TA (1994). "The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.". J. Immunol. 152 (9): 4582–9.  
  • Lecoanet-Henchoz S, Gauchat JF, Aubry JP; et al. (1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18.". Immunity 3 (1): 119–25.  
  • Garcìa-Barcina M, Winnock M, Bidaurrazaga I; et al. (1994). "Detection of cell-adhesion molecules on human liver-associated lymphocytes.". Immunology 82 (1): 95–8.  
  • Philippeaux MM, Vesin C, Tacchini-Cottier F, Piguet PF (1996). "Activated human platelets express beta2 integrin.". Eur. J. Haematol. 56 (3): 130–7.  
  • de Vree WJ, Fontijne-Dorsman AN, Koster JF, Sluiter W (1996). "Photodynamic treatment of human endothelial cells promotes the adherence of neutrophils in vitro.". Br. J. Cancer 73 (11): 1335–40.  
  • Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease.". Clin. Immunol. Immunopathol. 86 (2): 147–60.  
  • Shelley CS, Da Silva N, Georgakis A; et al. (1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb.". Genomics 49 (2): 334–6.  

External links

  • CD11c Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Mouse CD Antigen Chart
  • Human CD Antigen Chart
  • ITGAX Info with links in the Cell Migration Gateway

This article incorporates text from the United States National Library of Medicine, which is in the public domain.