CD18

CD18

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

PDB rendering based on 1l3y.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7
External IDs ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Integrin beta-2 (CD18) is a protein that in humans is encoded by the ITGB2 gene.

It is the beta subunit of four different structures:

The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.[1] In humans lack of CD18 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues.

Interactions

CD18 has been shown to interact with ICAM-1,[2][3][4] FHL2,[5] PSCD1[6][7] and GNB2L1.[8]

See also

References

  1. ^ "Entrez Gene: ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)". 
  2. ^ Kotovuori, A; Pessa-Morikawa T; Kotovuori P; Nortamo P; Gahmberg C G (June 1999). "ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity". J. Immunol. (UNITED STATES) 162 (11): 6613–20.  
  3. ^ Lu, C; Takagi J; Springer T A (May 2001). "Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state". J. Biol. Chem. (United States) 276 (18): 14642–8.  
  4. ^ Huang, C; Springer T A (August 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)". J. Biol. Chem. (UNITED STATES) 270 (32): 19008–16.  
  5. ^ Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78.  
  6. ^ Rietzler, M; Bittner M; Kolanus W; Schuster A; Holzmann B (October 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J. Biol. Chem. (UNITED STATES) 273 (42): 27459–66.  
  7. ^ Geiger, C; Nagel W, Boehm T, van Kooyk Y, Figdor C G, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber K S, Kolanus W (June 2000). "Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1". EMBO J. (ENGLAND) 19 (11): 2525–36.  
  8. ^ Liliental, J; Chang D D (January 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83.  

Further reading

External links