Carboprost

Carboprost

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Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF (specifically, it is 15-methyl-PGF) with oxytocic properties.

Carboprost induces contractions and can trigger abortion in early pregnancy. It also reduces postpartum bleeding.

Indication

Used in postpartum hemorrhage caused by uterine atony not controlled by other methods.
Unlabeled use:

  • Hemorrhagic Cystitis
  • PID

Contraindication

Contraindicated in severe cardiovascular, renal, and hepatic disease, also contraindicated in Pelvic Inflammatory Disease. Exert caution in asthmatic patients.

Precautions

  • asthma
  • anemia
  • jaundice
  • diabetes mellitus
  • seizure disorders
  • past uterine surgery

Adverse Effects

  • diarrhea (most common, may be sudden in onset)
  • fever
  • chills
  • nausea/vomiting

References

External links

  • Medical Subject Headings (MeSH)