Caroverine

Caroverine

Caroverine
Systematic (IUPAC) name
1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one
Clinical data
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number  YesY
ATC code A03
PubChem
ChemSpider  YesY
UNII  YesY
ChEMBL  N
Chemical data
Formula C22H27N3O2 
Mol. mass 365.47 g/mol
 N   

Caroverine (Spasmium, Spadon, Tinnex) is a drug used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.[1] It also has potent antioxidant effects.[1][2]

Applications

Caroverine has been demonstrated to have a high rate of efficacy in the treatment of cochlear-synaptic tinnitus.[3]

References

  1. ^ a b c Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H (2003). "The Antioxidant Activity of Caroverine".  
  2. ^ Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV (2003). "Caroverine, a Multifunctional Drug with Antioxidant Functions". BioFactors 19 (1–2): 79–85.  
  3. ^ Denk DM, Heinzl H, Franz P, Ehrenberger K. (Nov 1997). "Caroverine in tinnitus treatment. A placebo-controlled blind study.". Acta Oto-Laryngologica.