Caroxazone

Caroxazone

Caroxazone
Systematic (IUPAC) name
2-(2-oxo-4H-1,3-benzoxazin-3-yl)acetamide
Clinical data
Pregnancy cat.
  • ?
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
UNII  YesY
ChEMBL
Chemical data
Formula C10H10N2O3 
Mol. mass 206.20 g/mol

Caroxazone (Surodil, Timostenil) is an antidepressant which was formerly used for the treatment of depression but is now no longer marketed.[1][2] It acts as a reversible monoamine oxidase inhibitor (MAOI) of both MAO-A and MAO-B subtypes, with five-fold preference for the latter.[3][4][5][6][7]

See also

References

  1. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996.  
  2. ^ Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A (1978). "A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline". The Journal of International Medical Research 6 (5): 388–94.  
  3. ^ Lieberman, A. N. (1994). Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker.  
  4. ^ Moretti A, Caccia C, Martini A, et al. (May 1981). "Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers". British Journal of Clinical Pharmacology 11 (5): 511–5.  
  5. ^ Moretti A, Caccia C, Calderini G, Menozzi M, Amico A (October 1981). "Studies on the mechanism of action of caroxazone, a new antidepressant drug".  
  6. ^ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A (June 1981). "Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to oral tyramine in man". British Journal of Clinical Pharmacology 11 (6): 611–5.  
  7. ^ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A, Braibanti E (June 1981). "Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to intravenous tyramine in man". British Journal of Clinical Pharmacology 11 (6): 605–10.