Ceftibuten

Ceftibuten


Ceftibuten is a third-generation cephalosporin antibiotic. It is an orally administered agent, with two dosage forms, capsule or oral suspension. It is marketed by Pernix Therapeutics under the trade name Cedax.

Contents

  • Clinical use 1
    • Indications 1.1
    • Adverse reactions 1.2
    • Formulations 1.3
  • Spectrum of susceptibility 2
  • References 3
  • External links 4

Clinical use

Indications

Ceftibuten is used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis. It is also indicated for pneumonia, infections of the urinary tract, enteritis, and gastroenteritis.

Adverse reactions

In 3,000 patients, ceftibuten was well tolerated. The most frequent reactions were gastrointestinal and nauseas.

Formulations

Ceftibuten is available as capsules containing 400 mg, and a powder for oral suspension containing 180 mg per 5 ml.

Spectrum of susceptibility

Ceftibuten is active against Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, K. pneumoniae, K. oxytoca, Proteus vulgaris, P. mirabilis, P. providence, Salmonella sp., Shigella sp., Enterobacter sp. and Streptococcus sp.

The following represents MIC susceptibility data for a few clinically significant microorganisms:

  • Haemophilus influenzae - 0.015 µg/mL - 1 µg/mL
  • Moraxella catarrhalis - 0.5 µg/mL - 4 µg/mL
  • Streptococcus pneumoniae - 0.5 µg/mL - >256 µg/mL [1]

References

  1. ^ http://www.toku-e.com/Assets/MIC/Ceftibuten.pdf

External links

  • Manufacturer's website
  • Drug information from RxList