Ceftiofur
Systematic (IUPAC) name
(6R,7R)-7-[ [(2Z)-2-(2-Amino-1,3-thiazol-4-yl)- 2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
AHFS/Drugs.com
Legal status
?
Identifiers
CAS number  YesY
ATCvet code QJ01 QJ51
PubChem
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEMBL  YesY
Chemical data
Formula C19H17N5O7S3 
Mol. mass 523.56 g/mol
 YesY   

Ceftiofur is an antibiotic of the cephalosporin type (third generation), licensed for use in veterinary medicine. It was first described in 1987.[1] It is marketed by pharmaceutical company Pfizer as Excenel,[2] and is the active ingredient in that company's Specramast LC (lactating cow formula) product.

It is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against both Gram-positive and Gram-negative bacteria. E. coli strains resistant to ceftiofur have been reported.[3]

The metabolite desfurolyceftiofur also has antibiotic activity.[4] The two compounds are measured together to measure for antibiotic activity in milk (alongside other antibiotics).[5]

References

  1. ^ Yancey RJ, Kinney ML, Roberts BJ, Goodenough KR, Hamel JC, Ford CW (1987). "Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation in vitro and in vivo in mice". Am. J. Vet. Res. 48 (7): 1050–3.  
  2. ^ "Pfizer Animal Health Dairy Information on Products and Solutions". Retrieved 2007-11-20. 
  3. ^ Donaldson SC, Straley BA, Hegde NV, Sawant AA, DebRoy C, Jayarao BM (2006). "Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves". Appl. Environ. Microbiol. 72 (6): 3940–8.  
  4. ^ Salmon, S. A.; Watts, J. L.; Yancey, R. J. (1996). "In Vitro Activity of Ceftiofur and its Primary Metabolite, Desfuroylceftiofur, against Organisms of Veterinary Importance". Journal of Veterinary Diagnostic Investigation 8 (3): 332.  
  5. ^ "BetaStar Plus / For beta-lactam antibiotics / Product information sheet". Neogen. Retrieved 9 September 2014. 

External links

  • Official website