Like cephalosporins, cephamycins are based upon the cephem nucleus. Unlike most cephalosporins, cephamycins are a very efficient antibiotic against anaerobic microbes.
Cephamycins were originally produced by Streptomyces, but synthetic ones have been produced as well.
Cephamycins possess a methoxy group at the 7-alpha position.
In addition, cephamycins have been shown to be stable against extended-spectrum beta-lactamase (ESBL) -producing organisms, although their use in clinical practice is lacking for this indication.
- Oreste A. Mascaretti (2003). Bacteria Versus Antibacterial Agents: An Integrated Approach. American Society Microbiology. p. 144.
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- Benlloch M, Torres A, Soriano F (October 1982). "Cefmetazole (CS-1170): a new cephamycin with activity against gram-negative bacilli and staphylococci". J. Antimicrob. Chemother. 10 (4): 347–50.