Cholecystokinin receptor

Cholecystokinin receptor

cholecystokinin A receptor
Identifiers
Symbol CCKAR
Entrez 886
HUGO 1570
OMIM 118444
RefSeq NM_000730
UniProt P32238
Other data
Locus Chr. 4 p15.2-p15.1
cholecystokinin B receptor
Identifiers
Symbol CCKBR
Entrez 887
HUGO 1571
OMIM 118445
RefSeq NM_176875
UniProt P32239
Other data
Locus Chr. 11 p15.4

Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.

protein gene tissue distribution preferred ligand function
CCKA (CCK1) CCKAR primarily gastrointestinal tract, lesser amounts in the CNS sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
CCKB (CCK2) CCKBR primarily CNS, lesser amounts in the gastrointestinal tract gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides) regulation of nociception, anxiety, memory and hunger

References

  1. ^ Noble F, Wank SA,  
  2. ^ Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805–47.  

External links