Corticotropin releasing hormone receptor 1

Corticotropin releasing hormone receptor 1

Corticotropin releasing hormone receptor 1
3EHS.
Available structures
PDB Ortholog search: RCSB
Identifiers
CRHR1 Gene
RNA expression pattern

Corticotropin releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name.[1] In humans, CRF1 is encoded by the CRHR1 gene.[2][3]

Function

The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.[4]

CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.[5]

Clinical significance

Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma.[6]

CRF1 triggers cells to release hormones that are linked to stress and anxiety.[7] Hence CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.[8][9]

Interactions

Corticotropin releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone[10][11] and Urocortin.[12]

See also

References


Further reading

External links

  • Medical Subject Headings (MeSH)
  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.