D-Deprenyl

D-Deprenyl

D-Deprenyl
Systematic (IUPAC) name
(2S)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem
ChemSpider  N
Chemical data
Formula C13H17N 
Mol. mass 187.281 g/mol
 N   

D-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor, as well as prodrug to D-amphetamine and D-methamphetamine, and therefore a norepinephrine-dopamine releasing agent. It is the opposite enantiomer of L-deprenyl (selegiline).

L-Deprenyl, also an MAO-B inhibitor, metabolizes to L-amphetamine and l-methamphetamine, which are both monoamine releasing agents. In contrast, D-deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas L-Deprenyl is not know to have any appreciable psychological reinforcement.[1]

See also

References

  1. ^ Yasar S, Gaál J, Panlilio LV et al. (January 2006). "A comparison of drug-seeking behavior maintained by d-amphetamine, l-deprenyl (selegiline) and d-deprenyl under a second-order schedule in squirrel monkeys". Psychopharmacology 183 (4): 413–21.