|Dopamine receptor D2|
|RNA expression pattern|
Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
- C132T, G423A, T765C, C939T, C957T, and G1101A
- -141C insertion/deletion The polymorphisms has been investigated with respect to association with schizophrenia.
Most of the older antipsychotic drugs such as chlorpromazine and haloperidol are antagonists for the dopamine D2 receptor, but are, in general, very unselective, at best selective only for the "D2-like family" receptors and so binding to D2, D3 and D4, and often also to many other receptors such as those for serotonin and histamine, resulting in a range of side-effects and making them poor agents for scientific research. In similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D2 agonists, they affect other subtypes as well. Several selective D2 ligands are, however, now available, and this number is likely to increase as further research progresses.
- Aplindore - partial agonist
- Aripiprazole (Abilify in USA) - partial agonist
- Brexpiprazole/OPC-34712 - partial agonist
- GSK-789,472 - mixed D2 partial agonist / D3 antagonist, with good selectivity over other receptors 
- Talipexole - selective for D2 over other dopamine receptors, but also acts as α2-adrenoceptor agonist and 5-HT3 antagonist.
- OSU-6162 - D2 partial agonist and 5-HT2A partial agonist, acts as "dopamine stabilizer"
- Piribedil - also D3 receptor agonist and α2-adrenergic antagonist
- LSD - in vitro, LSD was found to be a partial agonist and potentiates dopamine-mediated prolactin secretion in lactotrophs. LSD is also a 5-HT2A agonist.
- Pramipexole - also D3, D4 receptor agonist
- Quinpirole - also D3 receptor agonist
- Salvinorin A - partial agonist. Also κ-opioid agonist.
- Bromocriptine - full agonist
- Ropinirole - full agonist
- Buspirone - partial agonist
- L-741,626 (3-[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole) - highly selective D2 antagonist
- Melperone - D2 antagonist but also 5-HT2A antagonist
- Raclopride - Radiolabled C11 Raclopride is commonly employed in Positron emission tomography studies
- Haloperidol - inverse agonist; which explains the severe extrapyramidal symptoms shown in patients
- Chlorpromazine (Thorazine)
- Risperidone (Risperdal) - D1, D2, D3, D4, D5, also 5-HT2A antagonist
- Ziprasidone (Geodon) - D1, D2, D3, D4, also 5-HT2A antagonist
- Quetiapine (Seroquel) - D1, D2, D3, D4, also 5-HT2A antagonist
- Olanzapine (Zyprexa) - D1, D2, D3, D4, also 5-HT2A antagonist
- Asenapine (Saphris) - D1, D2, D3, D4, also 5-HT2A antagonist
- Iloperidone (Fanapt) - D1, D2, D3, D4, also 5-HT2A antagonist
- Lurasidone (Latuda) - D2 also 5-HT2A antagonist
- Domperidone - D2 and D3 antagonist
- D2Sh selective (presynaptic autoreceptors)
- Medical Subject Headings (MeSH)