Dicyclomine

Dicyclomine

Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.

Medical uses

Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (IBS) (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.[1]

In the UK, it is an ingredient of a multi-ingredient preparation, together with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon.

In France, it is an ingredient of a multi-ingredient preparation, together with colchicine, under the brand Colchimax.

It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic.

Side effects

Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects.[1] Recreational use of this drug for its anticholinergic effects has been rarely reported.[1][2]

Caution

Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.[1]

Notes

References

  • Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
  • Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

External links