Systematic (IUPAC) name
Clinical data
Legal status
  • Withdrawn
Routes Oral
CAS number
ATC code None
Chemical data
Formula C20H25NO 
Mol. mass 295.42 g/mol

Difemetorex (INN; sold as Cleofil), also known as diphemethoxidine, is a stimulant drug of the piperidine class which was used as an appetite suppressant, but produced intolerable side effects such as insomnia which limited its clinical use.[1][2][3][4][5] It was introduced in France by Ciba-Geigy in 1966 but is now no longer marketed.[6]

See also


  1. ^ Isbell H, Chrusciel TS. Dependence Liability of Non-Narcotic Drugs. Bulletin of the World Health Organisation 1970; 43: Supplement.
  2. ^ Stepanek, J; Zolliker, VR (1971). "Circulatory effects of the anorectic Diphemethoxidine compared with the effects of Amphetamine and Aminorex". Archives internationales de pharmacodynamie et de therapie 191 (2): 376–99.  
  3. ^ Stepanek, J (1972). "Alteration of the acid-base equilibrium by the anorectic diphemethoxidine in comparison with the effect of amphetamine and aminorex". Archives internationales de pharmacodynamie et de therapie 199 (1): 122–38.  
  4. ^ Hall, Judith A.; Morton, Ian (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic.  
  5. ^ "The use of common stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Retrieved 2010-03-23. 
  6. ^ Brudon, Pascale (1983). Médicaments pour tous en l'an 2000?: les multinationales pharmaceutiques suisses face au tiers monde : l'exemple du Mexique. France: Editions d'En bas. p. 207.