2-methyl-1-nitro-3-[(tetrahydro-3-furanyl) methyl] guanidine
(RS)-1-methyl-2-nitro-3-[(tetrahydro-3-furanyl) methyl] guanidine; MTI-446
|Molar mass||202.21 g·mol−1|
|Lethal dose or concentration (LD, LC):|
LD50 (Median dose)
|≥2000 mg/kg (oral, rat and mouse)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Dinotefuran is an insecticide of the neonicotinoid class developed by Mitsui Chemicals for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers, sawflies, mole cricket, white grubs, lacebugs, billbugs, beetles, mealybugs, and cockroaches on leafy vegetables, in residential and commercial buildings, and for professional turf management. Its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors. In order to avoid harming beneficial insects such as bees, it should not be applied during bloom. 
In July of 2013, the state of Oregon temporarily restricted the use of dinotefuran pending the results of an investigation into a large bee kill.
- Dinotefuran, Mitsui Chemicals
- Dinotefuran Pesticide Fact Sheet, United States Environmental Protection Agency
- "Oregon Restricts Use of Certain Dinotefuran Pesticides", Pest Control Technology, 2 July 2013