|Systematic (IUPAC) name|
|Biological half-life||24-40 hours|
|CAS Registry Number|
|Molecular mass||281.392 g/mol|
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents. It has been shown to be useful in the treatment of Parkinsonism.
- Tradenames 1.1
- See also 2
- References 3
Diphenylpyraline, 4-diphenylmethoxy-1-methylpiperidine, is synthesized by alkylating 4-hydroxy-1-methylpiperidine with benzhydrylbromide.
- H.K. Lawrence, R. Kapp, U.S. Patent 2,479,843 (1949).
- W.A. Schuler, DE 934890 (1951).