Dipivefrine

Dipivefrine

Dipivefrine
Systematic (IUPAC) name
[2-(2,2-dimethylpropanoyloxy)-4- (1-hydroxy-2-methylamino-ethyl)- phenyl] 2,2-dimethylpropanoate
Clinical data
Trade names Propine
AHFS/Drugs.com
MedlinePlus
Pregnancy
category
  • US: B (No risk in non-human studies)
Identifiers
CAS Registry Number  Y
ATC code S01
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  N
Chemical data
Formula C19H29NO5
Molecular mass 351.437 g/mol
 N   

Dipivefrin (trade name Propine) is a prodrug of epinephrine, and is used to treat open-angle glaucoma.[1] It is available as a 0.1% ophthalmic solution.

Mechanism of action

The drug when applied over the cornea, penetrates it and is then hydrolysed to epinephrine by the esterases. It increases uveosacral outflow and also reduces aqueous formation (an α1 and α2 mediated action), thus reducing the intraocular pressure. It also increases the hydraulic conductivity of trabecular filtering cells (a β2 mediated action). It is preferred to epinephrine because it is longer acting, more consistent in its action and has better ocular tolerance.[1]

References

  1. ^ a b KD Tripari MD. Essentials of Medical Pharmacology (5 ed.). Jaypee Brothers Medical Publishers(P) Ltd. p. 88.