EGF module-containing mucin-like hormone receptor

EGF module-containing mucin-like hormone receptor

egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
Symbol EMR1
Alt. symbols TM7LN3
IUPHAR Entrez HUGO OMIM RefSeq UniProt Locus p13.3
egf-like module containing, mucin-like, hormone receptor-like 2
Identifiers
Symbol EMR2
IUPHAR Entrez HUGO OMIM RefSeq UniProt Locus p13.1
egf-like module containing, mucin-like, hormone receptor-like 3
Identifiers
Symbol EMR3
IUPHAR Entrez HUGO OMIM RefSeq UniProt Locus p13.1
egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene
Identifiers
Symbol EMR4P
Alt. symbols GPR127
Entrez HUGO RefSeq UniProt Locus p13.3

The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk.[1][2][3][4] There are four variants of EMR labeled 1-4, each encoded by a separate gene. These receptors are predominately expressed in cells of the immune system and bind ligands such as CD55.[5]

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