EGIS-12,233

EGIS-12,233

EGIS-12,233
Systematic (IUPAC) name
5,7-dichloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-indolin-2-one
Clinical data
Legal status
?
Identifiers
ATC code None
PubChem
Chemical data
Formula C24H28Cl3N3O 
Mol. mass 480.856 g/mol
 YesY   

EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.[1] It has been shown to increase dopamine release in cochlear tissue, suggesting a role for the 5-HT6 and 5-HT7 receptors in regulation of the hearing system.[2]

References

  1. ^ Volk, B; Barkóczy, J; Hegedus, E; Udvari, S; Gacsályi, I; Mezei, T; Pallagi, K; Kompagne, H et al. (2008). "(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists". Journal of Medical Chemistry 51 (8): 2522–32.  
  2. ^ Doleviczényi, Z;