ELK3

ELK3

ELK3, ETS-domain protein (SRF accessory protein 2)
Identifiers
Symbols  ; ERP; NET; SAP2
External IDs ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.[1][2] The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.[2]

Interactions

ELK3 has been shown to interact with TCF3.[3]

References

  1. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics 23 (3): 710–1.  
  2. ^ a b "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)". 
  3. ^ Maira, S M; Wurtz J M; Wasylyk B (Nov 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. (ENGLAND) 15 (21): 5849–65.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.