EP1 receptor

EP1 receptor

Prostaglandin E receptor 1 (subtype EP1), 42kDa
RNA expression pattern

Prostaglandin E receptor 1 (subtype EP1) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.[1]

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, Gq proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.[1]

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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.