V-ets avian erythroblastosis virus E26 oncogene homolog 2

PDB rendering based on 1k78.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; ETS2IT1
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Protein C-ets-2 is a protein that in humans is encoded by the ETS2 gene.[1][2] The protein encoded by this gene belongs to the ETS family of transcription factors.[1]


ETS2 has been shown to interact with ZMYND11,[3] ERG,[4] Cyclin-dependent kinase 10[5] and C-jun.[4] myb,[6]


  1. ^ a b Dwyer J, Li H, Xu D, Liu JP (Nov 2007). "Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family". Ann N Y Acad Sci 1114 (1): 36–47.  
  2. ^ "Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)". 
  3. ^ Wei, Guo; Schaffner Alicia Erbe; Baker Kimberly M; Mansky Kim C; Ostrowski Michael C (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Res. (Greece) 23 (3A): 2173–8.  
  4. ^ a b Basuyaux, J P; Ferreira E; Stéhelin D; Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". J. Biol. Chem. (UNITED STATES) 272 (42): 26188–95.  
  5. ^ Kasten, M; Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene (England) 20 (15): 1832–8.  
  6. ^ Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP (Feb 1992). "Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter". Proc Natl Acad Sci U S A 89 (4): 1291–5.  

Further reading

External links

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