Symbols  ; TBR2
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Eomesodermin also known as T-box brain protein 2 (TBR2) is a protein that in humans is encoded by the EOMES gene.[1]

This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.[1]

See also


  1. ^ a b "Entrez Gene: Eomesodermin". Retrieved 2011-11-01. 

Further reading

  • Kimura, N.; Nakashima, K.; Ueno, M.; Kiyama, H.; Taga, T. (1999). "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain". Brain research. Developmental brain research 115 (2): 183–193.  
  • Intlekofer, A. M.; Takemoto, N.; Wherry, E. J.; Longworth, S. A.; Northrup, J. T.; Palanivel, V. R.; Mullen, A. C.; Gasink, C. R.; Kaech, S. M.; Miller, J. D.; Gapin, L.; Ryan, K.; Russ, A. P.; Lindsten, T.; Orange, J. S.; Goldrath, A. W.; Ahmed, R.; Reiner, S. L. (2005). "Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin". Nature Immunology 6 (12): 1236–1244.  
  • Baala, L.; Briault, S.; Etchevers, H. C.; Laumonnier, F. D. R.; Natiq, A.; Amiel, J.; Boddaert, N.; Picard, C.; Sbiti, A.; Asermouh, A.; Attié-Bitach, T.; Encha-Razavi, F. R. C.; Munnich, A.; Sefiani, A.; Lyonnet, S. (2007). "Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis". Nature Genetics 39 (4): 454–456.  
  • Atreya, I.; Schimanski, C. C.; Becker, C.; Wirtz, S.; Dornhoff, H.; Schnürer, E.; Berger, M. R.; Galle, P. R.; Herr, W.; Neurath, M. F. (2007). "The T‐box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer". Gut 56 (11): 1572–1578.  
  • Araki, Y.; Fann, M.; Wersto, R.; Weng, N. P. (2008). "Histone Acetylation Facilitates Rapid and Robust Memory CD8 T Cell Response through Differential Expression of Effector Molecules (Eomesodermin and Its Targets: Perforin and Granzyme B)". Journal of immunology (Baltimore, Md. : 1950) 180 (12): 8102–8108.  
  • Sessa, A.; Mao, C. A.; Hadjantonakis, A. K.; Klein, W. H.; Broccoli, V. (2008). "Tbr2 Directs Conversion of Radial Glia into Basal Precursors and Guides Neuronal Amplification by Indirect Neurogenesis in the Developing Neocortex". Neuron 60 (1): 56–69.  
  • d’Cruz, L. M.; Rubinstein, M. P.; Goldrath, A. W. (2009). "Surviving the crash: Transitioning from effector to memory CD8+ T cell". Seminars in Immunology 21 (2): 92–98.  
  • Wang, H. T.; Ge, X. S.; Xue, Z. P.; Li, B. Q. (2010). "Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets". Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 26 (1): 31–34.  
  • Narayanan, S.; Silva, R.; Peruzzi, G.; Alvarez, Y.; Simhadri, V. R.; Debell, K.; Coligan, J. E.; Borrego, F. (2010). Unutmaz, Derya, ed. "Human Th1 Cells That Express CD300a Are Polyfunctional and After Stimulation Up-Regulate the T-Box Transcription Factor Eomesodermin". PLoS ONE 5 (5): e10636.  
  • Kinjyo, I.; Gordon, S. M.; Intlekofer, A. M.; Dowdell, K.; Mooney, E. C.; Caricchio, R.; Grupp, S. A.; Teachey, D. T.; Rao, V. K.; Lindsten, T.; Reiner, S. L. (2010). "Lymphoproliferation Caused by Fas Deficiency is Dependent on the Transcription Factor Eomesodermin". The Journal of Immunology 185 (12): 7151–7155.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.