Eseroline

Eseroline

Eseroline
Systematic (IUPAC) name
(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol
Identifiers
CAS Registry Number  YesY
ATC code None
PubChem CID:
ChemSpider
ChEBI
Synonyms Eseroline
Chemical data
Formula C13H18N2O
Molecular mass 218.295 g/mol
 YesY   

Eseroline is a drug which acts as an opioid agonist.[1] It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline is weak and easily reversible,[2][3] and it produces fairly potent analgesic effects mediated through the μ-opioid receptor.[4] This mixture of activities gives eseroline an unusual pharmacological profile,[5][6] although its uses are limited by side effects such as respiratory depression[7] and neurotoxicity.[8]

References

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