Fenarimol

Fenarimol

Fenarimol
Identifiers
CAS number
PubChem
ChEBI
Jmol-3D images Image 1
Properties
Molecular formula C17H12Cl2N2O
Molar mass 331.20 g mol−1
Appearance Colorless powder with aromatic odour
Melting point 117 to 119 °C (243 to 246 °F; 390 to 392 K)[1]
Boiling point 240 °C (464 °F; 513 K) (decomposition)[1]
Solubility in water 13.7 mg·L-1 at 25 °C
Solubility soluble in acetone, xylene and methanol[1]
Vapor pressure 65 μ Pa (25 °C)[1]
Hazards
LD50 >2000 mg·kg−1 (oral, Ratte)[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)

Fenarimol, sold under the tradenames Bloc, Rimidin and Rubigan, is a fungicide which acts against rusts, blackspot and mildew fungi. It is used on ornamental plants, trees, lawns, tomatoes, peppers, eggplants, cucumbers and melons. It is mainly used to control powdery mildew. It works by inhibiting the fungus's biosynthesis of important steroid molecules.[2]

Description

Fenarimol was developed by Eli Lilly & Company around 1971.[3]

Health Risk

Fenarimol can lead to increased growth of MCF7 breast cancer cells.[4]

Synthesis

Fenarimol is made by the reaction of a diarylketon with an organolithium derived by halogen-metal exchange.[2]

Fenarimolsynth

External Links

  • Pesticide Properties Database (PPDB) record for Fenarimol


References

  1. ^ a b c d e EU-Data.
  2. ^ a b Organic chemistry (Reprinted (with corrections) ed.). Oxford [u.a.]: Oxford Univ. Press. 2005. p. 216.  
  3. ^ GB 1218623  "Substituted-5-pyrimidine compounds "
  4. ^ Vinggaard, Anne Marie; Breinholt, Vibeke; Larsen, John Christian (1 December 1999). "Screening of selected pesticides for oestrogen receptor activation in vitro". Food Additives and Contaminants 16 (12): 533–542.