|Systematic (IUPAC) name|
|Mol. mass||339.446 g/mol|
Fluorophen is an opioid drug of the benzomorphan family which was developed as a radioligand for the purpose of labeling opioid receptors during PET scans (with 18F). Unlike most other benzomorphan derivatives, fluorophen acts as a full agonist of the opioid receptors with preferential affinity for the μ-opioid receptor (approximately 6x that of morphine), similar but slightly lower affinity for the δ-opioid receptor (equipotent to [D-Ala2, D-Leu5]enkephalin), and very low affinity for the κ-opioid receptor.
- Rice KC, Konicki PE, Quirion R, Burke TR, Pert CB (November 1983). "Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo". Journal of Medicinal Chemistry 26 (11): 1643–5.
- Cody Paul Coyne (9 January 2008). Comparative Diagnostic Pharmacology: Clinical and Research Applications in Living-System Models. John Wiley & Sons. p. 692.