Fusaric acid

Fusaric acid

Fusaric acid
Names
IUPAC name
5-Butylpyridine-2-carboxylic acid
Other names
5-Butylpicolinic acid

Fusarinic acid

Picolinic acid, 5-butyl-
Identifiers
 YesY
ChemSpider  N
EC number 208-643-0
Jmol-3D images Image
KEGG  N
MeSH
PubChem
Properties
C10H13NO2
Molar mass 179.22 g·mol−1
Melting point 97 to 98 °C (207 to 208 °F; 370 to 371 K)
Related compounds
Related compounds
picolinic acid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: YesY/N?)

Fusaric acid is a picolinic acid derivative.

Antibiotic (wilting agent) first isolated from the fungus Fusarium heterosporium.[1]

It is typically isolated from various Fusarium species, and has been proposed for a various therapeutic applications. However, it is primarily used as a research tool.

Its mechanism of action is not well understood. It likely inhibits Dopamine beta-hydroxylase (the enzyme that converts dopamine to norepinephrine). It may also have other actions, such as the inhibition of cell proliferation and DNA synthesis.

It is used to make bupicomide.

References

  1. ^ Yabuta et al., J. Agric. Chem. Soc. Jpn. 10, 1059 (1934).