GABA transaminase inhibitor

GABA transaminase inhibitor

A GABA transaminase inhibitor is an enzyme inhibitor that acts upon GABA transaminase.[1]

Examples include valproic acid,[2] vigabatrin,[3][4] phenylethylidenehydrazine, ethanolamine-O-sulfate (EOS), and L-cycloserine.[5]

Certain members of this class are used as anticonvulsants.

There is some evidence that Melissa officinalis (lemon balm), and rosmarinic acid it contains, inhibits GABA transaminase.[6]

References

  1. ^ Ciesielski, L.; Simler, S.; Gensburger, C.; Mandel, P.; Taillandier, G.; Benoit-Guyod, J. L.; Boucherle, A.; Cohen-Addad, C.; Lajzerowicz, J. (1979). "GABA transaminase inhibitors". Advances in experimental medicine and biology. Advances in Experimental Medicine and Biology 123: 21–41.  
  2. ^ Bruni, J.; Wilder, B. J. (1979). "Valproic acid. Review of a new antiepileptic drug". Archives of neurology 36 (7): 393–398.  
  3. ^ Wang QP, Jammoul F, Duboc A, et al (April 2008). "Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina". Eur. J. Neurosci. 27 (8): 2177–87.  
  4. ^ Gibson, J. P.; Yarrington, J. T.; Loudy, D. E.; Gerbig, C. G.; Hurst, G. H.; Newberne, J. W. (1990). "Chronic toxicity studies with vigabatrin, a GABA-transaminase inhibitor". Toxicologic pathology 18 (2): 225–238.  
  5. ^ Polc, P.; Pieri, L.; Bonetti, E. P.; Scherschlicht, R.; Moehler, H.; Kettler, R.; Burkard, W.; Haefely, W. (1986). "L-cycloserine: Behavioural and biochemical effects after single and repeated administration to mice, rats and cats". Neuropharmacology 25 (4): 411–418.  
  6. ^ Awad, R.; Levac, D.; Cybulska, P.; Merali, Z.; Trudeau, V. L.; Arnason, J. T. (2007). "Effects of traditionally used anxiolytic botanicals on enzymes of the γ -aminobutyric acid (GABA) systemThis article is one of a selection of papers published in this special issue (part 1 of 2) on the Safety and Efficacy of Natural Health Products". Canadian Journal of Physiology and Pharmacology 85 (9): 933–942.