G protein-coupled receptor 64
GPR64 Gene
RNA expression pattern

G-protein coupled receptor 64 Is a protein that in humans is encoded by the GPR64 gene. The gene product is a member of the It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[1][2] [3][4][5][6]

The adhesion GPCR, GPR64, is an orphan receptor characterized by a long N-terminus with that has been suggested to be highly glycosylated.[7] GPR64's N-terminus has been reported to be cleaved at the GPS domain to allow for trafficking to the plasma membrane. After cleavage the N-terminus is believed to remain non-covalently associated with the 7TM. Male mice lacking GPR64 are infertile.

GPR64 expression has been mostly reported in the male reproductive organs, but more recently has been shown to be expressed in the central nervous system.[8]


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