Hydroxycarboxylic acid receptor 1
HCAR1 Gene
RNA expression pattern

G protein-coupled receptor 81, also known as GPR81, is a protein that in humans is encoded by the GPR81 gene.[1][2]

G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[1]

Lactate activates the GPR81 receptor which in turn inhibits lipolysis in fat cells.[3][4]


Further reading