GRIN2B

GRIN2B

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B
1S11.
Available structures
PDB Ortholog search: RCSB
Identifiers
GRIN2B Gene
RNA expression pattern

Glutamate [NMDA] receptor subunit epsilon-2 also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B) is a protein that in humans is encoded by the GRIN2B gene.[1]

Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.[2]

Ligands

  • Besonprodil
  • Eliprodil
  • Evt 101, a selctive NR2B receptor antagonist, is being tested as a potentially fast acting antidepressant.[3]

Interactions

GRIN2B has been shown to interact with LIN7B,[4] DLG4,[5][6][7][8][9][10] DLG2,[6][7] DLG3,[5][6][7][9] EXOC4,[5] RICS[11] and Actinin, alpha 2.[12]

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.