GYKI-52466

GYKI-52,466[1][2][3][4][5][6][7]
Identifiers
CAS number 102771-26-6 YesY
192065-56-8 (HCl salt)
PubChem 3538
Jmol-3D images Image 1
Properties
Molecular formula C17H15N3O2
Molar mass 293.32 g/mol
Appearance Yellow solid (HCl salt)
Density 1.393 g/cm3
Solubility in water >10 mg/mL (HCl salt)
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

GYKI-52466 is a 2,3-benzodiazepine that acts as an ionotropic glutamate receptor antagonist, which is a non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively), orally-active anticonvulsant, and skeletal muscle relaxant. Unlike conventional 4,5-benzodiazepines, GYKI-52466 and related 2,3-benzodiazepines do not act on GABA-A receptors. Like other AMPA receptor antagonists, GYKI-52466 has anticonvulsant and neuroprotective properties.

References