Gastric chief cell

Gastric chief cell

Chief cell
H&E stain of fundic gland polyp showing shortening of the gastric pits with cystic dilatation
A fundus gland. A. Transverse section of gland.
Latin exocrinocytus principalis
Code TH H3.

A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a cell in the stomach that releases pepsinogen, gastric lipase and chymosin.[1] The cell stains basophilic upon H&E prep due to the large proportion of rough endoplasmic reticulum in its cytoplasm.

Chief cells release the zymogen (enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic activity from the vagus nerve and acidic condition in the stomach. Gastrin and secretin may also act as secretagogues.[2]

It works in conjunction with the parietal cell, which releases gastric acid, converting the pepsinogen into pepsin.

See also


External links

  • Anatomy Atlases - Microscopic Anatomy, plate 01.05
  • 22201loa - "Ultrastructure of the Cell: chief cells and enteroendocrine cell"
  • 11304loa - "Digestive System: Alimentary Canal: fundic stomach, gastric glands, base"
  • "Dorland's Medical Dictionary
  • Physiology at MCG 6/6ch4/s6ch4_8