Gemazocine

Gemazocine

Gemazocine
Systematic (IUPAC) name
10-(cyclopropylmethyl)-1-ethyl-13,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-trien-4-ol
Clinical data
Legal status
?
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
Chemical data
Formula C20H29NO 
Mol. mass 299.450 g/mol

Gemazocine (R-15,497), also known as cyclogemine, is a non-selective opioid antagonist of the benzomorphan class.[1][2][3] It may have partial agonist properties at some of the opioid receptors, such as at the kappa receptor (as it induces dysphoric effects in humans), but seems to be generally antagonistic in its actions.[4]

References

  1. ^ Macdonald, F. (1997). Dictionary of Pharmacological Agents. CRC Press. p. 955.  
  2. ^ Gelders, Y. G.; de Ranter, C. J.; Schenk, H. (1979). "Structural Studies of Substituted 6,7-Benzomorphan Compounds. I. The Absolute Configuration of (−)-2-Cyclopropylmethyl-2'-hydroxy-5-ethyl-9,9-dimethyl-6,7-benzomorphan (Gemazocine) Hydrobromide". Acta Crystallographica B 35 (3): 699–703.  
  3. ^ Verlinde C, De Ranter C (August 1988). "Assessment of the kappa-opioid activity of a series of 6,7-benzomorphans in the rabbit vas deferens". Eur. J. Pharmacol. 153 (1): 83–7.  
  4. ^ Freye, E.; Hartung, E.; Schenk, G. K. (1983). "Bremazocine: An Opiate That Induces Sedation and Analgesia without Respiratory Depression" (pdf). Anesthesia and Analgesia 62 (5): 483–488.