L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor[1] which may have potential for the treatment of Alzheimer's disease[2] and dementia.[3] Alpha-GPC is also used as a nootropic dietary supplement to enhance memory and cognition[4]

Alpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter.[2] Alpha-GPC is derived from highly purified soy lecithin.

Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance.[5] It is produced synthetically by the deacylation of soya phospholipids. Commonly used doses are 300 to 1,200 mg daily.