Histone deacetylase 2
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene.[1]

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.[2]


Histone deacetylase 2 has been shown to interact with:

See also


Further reading

External links

  • Medical Subject Headings (MeSH)