HZ-2

HZ-2

HZ-2
Systematic (IUPAC) name
Dimethyl 3,7-dimethyl-9-oxo-2,4-dipyridin-2-yl-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate
Clinical data
Legal status
?
Identifiers
CAS number
ATC code ?
PubChem
Chemical data
Formula C23H26N4O5 
Mol. mass 438.475 g/mol
 YesY   

HZ-2 is a drug which acts as a highly selective κ-opioid agonist.[1] It is a potent analgesic with around the same potency as morphine, with a long duration of action and high oral bioavailability.[2][3] Side effects include sedation, nausea and dysphoria as well as diuretic effects.[4]

References

  1. ^ Siener, T; Cambareri, A; Kuhl, U; Englberger, W; Haurand, M; Kögel, B; Holzgrabe, U (2000). "Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones". Journal of Medical Chemistry 43 (20): 3746–51.  
  2. ^ Holzgrabe, U; Cambareri, A; Kuhl, U; Siener, T; Brandt, W; Strassburger, W; Friderichs, E; Englberger, W et al. (2002). "Diazabicyclononanones, a potent class of kappa opioid analgesics". Farmaco (Societa chimica italiana : 1989) 57 (7): 531–4.  
  3. ^ Holzgrabe, U; Brandt, W (2003). "Mechanism of action of the diazabicyclononanone-type kappa-agonists". Journal of Medical Chemistry 46 (8): 1383–9.  
  4. ^ Kögel, B; Christoph, T; Friderichs, E; Hennies, HH; Matthiesen, T; Schneider, J; Holzgrabe, U. (1998). "HZ2, a Selective Kappa-Opioid Agonist". CNS Drug Reviews 4 (1): 54–70.