Hexobarbital

Hexobarbital

Hexobarbital
Systematic (IUPAC) name
(RS)-5-(cyclohex-1-en-1-yl)-1,5-dimethyl-1,3-diazinane-2,4,6-trione
Pharmacokinetic data
Protein binding 25%
Identifiers
CAS Registry Number  YesY
50-09-9 (sodium salt)
ATC code N01 N05
PubChem CID:
DrugBank  YesY
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEBI  YesY
ChEMBL  YesY
Chemical data
Formula C12H16N2O3
Molecular mass 236.267 g/mol
 YesY   

Hexobarbital (as known in the US), or hexobarbitone (as known elsewhere), sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal (usually in 250-mgm. strength tablets), is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery, as well as a rapid-acting, short-lasting hypnotic for general use, and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine; usually thiopental would be the barbiturate of choice for this application these days. Hexobarbital is still used in some scientific research.

Further reading