Classification and external resources
ICD-9 781.1

Hyperosmia is an increased olfactory acuity (heightened sense of smell), usually caused by a lower threshold for odor.[1] This perceptual disorder arises when there is an abnormally increased signal at any point between the olfactory receptors and the olfactory cortex. The causes of hyperosmia may be genetic, environmental or the result of benzodiazepine withdrawal syndrome.


  • Background: the olfactory system 1
  • Genetic causes 2
  • Environmental causes 3
  • Treatment 4
  • See also 5
  • References 6

Background: the olfactory system

When odorants enter the nasal cavity, they bind to odorant receptors at the base of the olfactory epithelium. These receptors are bipolar neurons that connect to the glomerular layer of the olfactory bulb, traveling through the cribriform plate.[2] At the glomerular layer, axons from the olfactory receptor neurons intermingle with dendrites from intrinsic olfactory bulb neurons: mitrial/tufted cells and dopaminergic periglomerular cells. From the olfactory bulb, mitral/tufted cells send axons via the lateral olfactory tract (the cranial nerve I) to the olfactory cortex, which includes the piriform cortex, entorhinal cortex, and parts of the amygdala.[2] From the entorhinal cortex, axons extend to the medial dorsal nucleus of the thalamus, which then proceed to the orbitofrontal cortex.[2]

Genetic causes

A study by Menashe et al. has found that individuals with a single nucleotide polymorphism variant in the OR11H7P pseudogene have a lower receptor activation threshold for isovaleric acid.[3] These individuals are hyperosmic for this single odorant.

Another study by Keller et al. has found that people with the intact human odorant receptor OR7D4 are more sensitive to androstenone and androstadienone and thus find them unpleasant (individuals with the semi-functional OR7D4 have two non-synonymous single nucleotide polymorphisms in the OR7D4 pseudogene, resulting in two amino acid substitutions).[4] There has not yet been extensive research into the genetic background of those with general hyperosmia, rather than for just a single odorant.

Environmental causes

There has not been extensive research into environmental causes of hyperosmia, but there are some theories of some possible causes. In a study by Atianjoh et al., it has been found that amphetamines decrease levels of dopamine in the olfactory bulbs of rodents.[5] On this basis, it has been hypothesized that amphetamine use may cause hyperosmia in rodents and humans, but further research is still needed. This theory is supported indirectly by the fact that patients with Parkinson’s Disease have an increase in dopaminergic cells in the olfactory bulb and usually exhibit hyposmia.[5] Anecdotal support for the idea that amphetamines may cause hyperosmia comes from Oliver Sacks’ account of a patient with a heightened sense of smell after taking amphetamines.[6] It has also been observed that the inhalation of hydrocarbons can cause hyperosmia, most likely due to destruction of dopaminergic neurons in the olfactory bulb.[7] Methotrexate, administered in the treatment of psoriasis, has been known to cause hyperosmia, and is more likely to do so in patients with a history of migraines.[8] However, this is only an observation and not part of a study; therefore it has not yet been verified.


Normal olfactory acuity will usually return over time if the cause is environmental, even if it is untreated.[6][7] The hyperosmic person may need to be removed from strong odorants for a period of time if the sensation becomes unbearable.[7] Before they had been discontinued due to undesirable side effects, butyrophenones or thioridazine hydrochloride, both of which are dopamine antagonists, have been used to treat hyperosmia.[7]

See also


  1. ^ Walker, HK (1990). Clinical Methods: The History, Physical, and Laboratory Examinations. Boston: Butterworths. pp. Ch 59. 
  2. ^ a b c Bear, Mark (2007). Neuroscience: Exploring the Brain. New York: Lippincott Williams and Wilkins. pp. 265–274.  
  3. ^ Menashe, I; Abaffy, T; Hasin, Y; Goshen, S; Yahalom, V; Luetje, CW; Lancet, D (2007-10-30). "Genetic elucidation of human hyperosmia to isovaleric acid.". PLoS Biology 5 (11): e284.  
  4. ^ Keller, A; Zhuang, H; Chi, Q; Vosshall, LB; Matsunami, H (2007-09-27). "Genetic variation in a human odorant receptor alters odour perception.". Nature 449 (7161): 468–72.  
  5. ^ a b Atianjoh, FE; Ladenheim, B; Krasnova, IN; Cadet, JL (2008-07-28). "Amphetamine causes dopamine depletion and cell death in the mouse olfactory bulb.". European Journal of Pharmacology 589 (1-3): 94–7.  
  6. ^ a b Sacks, Oliver (1985). The Man Who Mistook His Wife for a Hat. New York: Simon & Schuster. pp. 156–160.  
  7. ^ a b c d Henkin, RI (1990-12-05). "Hyperosmia and depression following exposure to toxic vapors.". JAMA : the Journal of the American Medical Association 264 (21): 2803.  
  8. ^ Zargari, O (2006-12-10). "Methotrexate, hyperosmia, and migraine.". Dermatology Online Journal 12 (7): 28.