Hypocretin (orexin) receptor 2

Hypocretin (orexin) receptor 2

Hypocretin (orexin) receptor 2
Identifiers
HCRTR2 Gene
RNA expression pattern
Orexin receptor type 2
Identifiers
Symbol Orexin_rec2
Pfam InterPro IPR004060

Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2, is a protein that in humans is encoded by the HCRTR2 gene.[1]

Function

OX2 is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with OX1. OX2 binds both orexin A and orexin B neuropeptides. OX2 is involved in the central feedback mechanism that regulates feeding behaviour.[1]

Ligands

Agonists

Antagonists

  • Almorexant - mixed OX1/2 antagonist
  • SB-649,868 - mixed OX1/2 antagonist
  • TCS-OX2-29 - selective OX2 antagonist
  • 1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)urea (600x selective for OX2 over OX1)[2]
  • (3,4-dimethoxyphenoxy)alkylamino acetamides [3]

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.