ING1

ING1

Inhibitor of growth family, member 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3] This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

Interactions

ING1 has been shown to interact with HDAC1,[4][5] DMAP1,[6] PCNA,[7] SIN3A,[5] SAP30,[5] P53,[8][9] SMARCC1,[5] CREB binding protein[4] and SMARCA4.[5]

References

  1. ^ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nat Genet 14 (4): 415–20.  
  2. ^ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenet Cell Genet 76 (3-4): 176–8.  
  3. ^ a b "Entrez Gene: ING1 inhibitor of growth family, member 1". 
  4. ^ a b Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". J. Biol. Chem. (United States) 277 (33): 29832–9.  
  5. ^ a b c d e Kuzmichev, A; Zhang Y; Erdjument-Bromage H; Tempst P; Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Mol. Cell. Biol. (United States) 22 (3): 835–48.  
  6. ^ Xin, Huawei; Yoon Ho-Guen; Singh Prim B; Wong Jiemin; Qin Jun (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". J. Biol. Chem. (United States) 279 (10): 9539–46.  
  7. ^ Scott, M; Bonnefin P; Vieyra D; Boisvert F M; Young D; Bazett-Jones D P; Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". J. Cell. Sci. (England) 114 (Pt 19): 3455–62.  
  8. ^ Leung, Ka Man; Po Lai See; Tsang Fan Cheung; Siu Wai Yi; Lau Anita; Ho Horace T B; Poon Randy Y C (Sep 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Res. (United States) 62 (17): 4890–3.  
  9. ^ Garkavtsev, I; Grigorian I A; Ossovskaya V S; Chernov M V; Chumakov P M; Gudkov A V (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control".  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.