|Inhibitor of growth family, member 4|
PDB rendering based on 1wen.
|Symbols||; my036; p29ING4|
|RNA expression pattern|
Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene. The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.
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- "Entrez Gene: ING4 inhibitor of growth family, member 4".
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- Zhang X, Lin DH, Jin Y, et al. (2007). "Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation.". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9517–22.
- ING4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)