|Systematic (IUPAC) name|
|Mol. mass||248.277 g/mol|
Indorenate (TR-3369), is a tryptamine derivative which acts as an agonist at the 5-HT1A, 5-HT1B and 5-HT2C serotonin receptors. It has anxiolytic, antihypertensive and anorectic effects, predominantly through action at 5-HT1A, but with some contribution from the 5-HT1B and 5-HT2C subtypes, and possibly some other non-serotonergic targets also.
- Antonaccio MJ, Kerwin L (1981). "On the effects and mechanism of action of the antihypertensive agent TR 3369 (5-methoxytryptamine beta-methylcarboxylate) in spontaneously hypertensive rats". Journal of Cardiovascular Pharmacology 3 (6): 1306–11.
- Schoeffter P, Hoyer D (November 1988). "Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus".
- Fernández-Guasti A, Escalante A, Hong E, Agmo A (September 1990). "Behavioural actions of the serotonergic anxiolytic indorenate". Pharmacology, Biochemistry, and Behavior 37 (1): 83–8.
- López Cabrera M, Velázquez Martínez DN, Prado R, García G, Ortiz R (1991). "Effects of the intracerebroventricular administration of indorenate and fenfluramine on spontaneous behavior and food intake in rats". Proceedings of the Western Pharmacology Society 34: 465–8.
- Velázquez-Martínez DN, López Cabrera M, Sánchez H, Ramírez JI, Hong E (March 1999). "Discriminative stimulus properties of indorenate, a serotonin agonist". Journal of Psychiatry & Neuroscience : JPN 24 (2): 122–30.
- Sánchez H, Velázquez-Martínez DN (March 2001). "Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats". Journal of Psychopharmacology (Oxford, England) 15 (1): 29–36.
- Miranda F, Orozco G, Velázquez-Martínez DN (July 2002). "Full substitution of the discriminative cue of a 5-HT(1A/1B/2C) agonist with the combined administration of a 5-HT(1B/2C) and a 5-HT(1A) agonist". Behavioural Pharmacology 13 (4): 303–11.
- Miranda F, Hong E, Sánchez H, Velázquez-Martínez DN (January 2003). "Further evidence that the discriminative stimulus properties of indorenate are mediated by 5-HT 1A/1B/2C receptors". Pharmacology, Biochemistry, and Behavior 74 (2): 371–80.
- López-Meraz ML, Neri-Bazán L, Rocha L (September 2006). "Indorenate modifies a1-adrenergic and benzodiazepine receptor binding in the rat brain: an autoradiography study". The Journal of Pharmacy and Pharmacology 58 (9): 1243–8.