Isopropamide

Isopropamide

Isopropamide
Systematic (IUPAC) name
4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium
Clinical data
MedlinePlus
Legal status
  • US: Rx-only, Unscheduled
  • Unscheduled
Routes of
administration
Oral
Identifiers
CAS Registry Number  N
ATC code A03
PubChem CID:
DrugBank  YesY
ChemSpider  YesY
UNII  YesY
ChEMBL  N
Chemical data
Formula C23H33N2O+
Molecular mass 353.52092 g/mol
 N   

Isopropamide (R5) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

  • Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.
  • Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.