JWH-081

JWH-081

JWH-081
Systematic (IUPAC) name
4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone
Clinical data
Legal status
Identifiers
CAS Registry Number  YesY
PubChem CID:
ChemSpider
Chemical data
Formula C25H25NO2
Molecular mass 371.47 g/mol
 YesY   

JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors.[2] With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype approximately 10x the affinity at CB2.[3] It was discovered by and named after Dr. John W. Huffman.

Legal Status

As of October 2015 JWH-081 is a controlled substance in China.[4]

See also

References

  1. ^
  2. ^ Aung MM, et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 2000; 60:133-140.
  3. ^ Huffman JW, et al. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorganic and Medicinal Chemistry. 2005; 13:89-112.
  4. ^