Potassium inwardly-rectifying channel, subfamily J, member 4
Available structures
PDB Ortholog search: RCSB
KCNJ4 Gene
RNA expression pattern

Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or Kir2.3, is a human gene.[1]

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.[1]


KCNJ4 has been shown to interact with LIN7C,[2][3] LIN7B,[4] DLG4,[3][5][6] DLG1[2][3][7] and CASK.[2][3]

See also


Further reading

External links

  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.