Ketazocine

Ketazocine

Ketazocine
Systematic (IUPAC) name
(2S,6R,11R)-3-(cyclopropylmethyl)-8-hydroxy-6,11-dimethyl-3,4,5,6-tetrahydro-2,6-methano-3-benzazocin-1(2H)-one
Clinical data
Legal status
  • ?
Routes Oral
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  YesY
UNII  YesY
KEGG  YesY
Chemical data
Formula C18H23NO2 
Mol. mass 285.38 g/mol
 YesY   

Ketazocine (INN), also known as ketocyclazocine, is a benzomorphan derivative used in opioid receptor research. Ketocyclazocine is an exogenous opioid that binds to the kappa opioid receptor.[1]

Activation of this receptor causes a decrease in pain sensations and increased sleepiness but can also cause psychological symptoms such as dysphoria, paranoia, and hallucinations. It also causes an increase in urine production because it inhibits the release of vasopressin. (Vasopressin is an endogenous substance that assists in regulating fluid and electrolyte balance in the body and decreases the amount of water released into the urine.)

Unlike other opioids, substances that only bind to the kappa receptor theoretically do not depress the respiratory system.

See also

References

  1. ^ Leander JD (Sep 1982). "Effects of ketazocine, ethylketazocine and phenazocine on schedule-controlled behavior: antagonism by naloxone". Neuropharmacology 21 (9): 923–8.