|Molecular mass||1484.00 g/mol|
Lipo-oxytocin-1 (LOT-1) is a synthetic peptide and analogue of oxytocin that acts as an agonist of the oxytocin receptor. The lipidation strategy was applied to oxytocin to create a new peptide with improved pharmacokinetics. LOT-1 consists of oxytocin conjugated with two palmitoyl groups. After adjusting for molecular weight (LOT-1 is ~1.5x the weight of oxytocin), oxytocin and LOT-1 are equipotent. In addition, LOT-1 appears to have a significantly longer duration of effect relative to that of oxytocin. It has yet to be determined whether LOT-1 possesses improved blood-brain-barrier permeability relative to oxytocin.
- Mizuno A, Cherepanov SM, Kikuchi Y, Fakhrul AA, Akther S, Deguchi K, Yoshihara T, Ishihara K, Shuto S, Higashida H (2015). "Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice" (PDF). Brain Sci 5 (1): 3–13.