Litoxetine

Litoxetine

Litoxetine
Systematic (IUPAC) name
4-(naphthalen-2-ylmethoxy)piperidine
Clinical data
Legal status
?
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
UNII  YesY
ChEMBL
Chemical data
Formula C16H19NO 
Mol. mass 241.327 g/mol

Litoxetine (SL 81-0385) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s.[1] It acts as a serotonin reuptake inhibitor and 5-HT3 receptor antagonist. It has prominent antiemetic properties, and unlike the selective serotonin reuptake inhibitors (SSRIs), it was shown to have a negligible incidence of nausea and emesis.[2] Development of litoxetine for medicinal use was apparently halted in the late 1990s.

References

  1. ^ Fairweather DB, Patat A, Rosenzweig P, Curson VH, Dunmore C, Dubruc C, Hindmarch I (August 1995). "The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers". British Journal of Clinical Pharmacology 40 (2): 119–25.  
  2. ^ Angel I, Schoemaker H, Prouteau M, Garreau M, Langer SZ (March 1993). "Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties". European Journal of Pharmacology 232 (2-3): 139–45.